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BeitragVerfasst: Di Jan 08, 2013 10:10 pm 
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Beiträge: 47
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1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthase.

http://www.ncbi.nlm.nih.gov/pmc/article ... 318844.pdf

Zitat:
High homocysteine (HCY) levels are a risk factor for osteoporotic fracture. Furthermore, bone quality and strength are compromised by elevated HCY owing to its negative impact on collagen maturation. HCY is cleared by cystathionine β-synthase (CBS), the first enzyme in the transsulfuration pathway.

Zitat:
To further explore the potential clinical relevance of our ex vivo findings, human data from the Longitudinal Aging Study Amsterdam suggested a correlation between vitamin D status [25(OH)D(3) levels] and HCY levels. In conclusion, this study showed that cbs is a primary 1,25(OH)(2) D(3) target gene which renders HCY metabolism responsive to 1,25(OH)(2) D(3).

Zitat:
From our data, we can conclude that there is an association between the 25(OH)D3 status and the amount of HCY in serum. This effect is relatively small compared to the HCY lowering effects of other vitamins, such as the B vitamins but 1,25(OH)2D3 may support the action of folic acid, vitamin B6, and B12 in lowering high HCY levels.(42) Nevertheless, this beneficial effect of 1,25(OH)2D3 on HCY levels adds to the multitude of positive effects linked to an optimal vitamin D status.

Diesel

_________________
B12 hydroxo- injecties ’95. Sublingaal methyl- en adenosyl-cobalamine tabl. ’08. Osteoporose '07. Koper en ceruloplasmine deficiëntie ’08. Sinds 2010 MP. med. q6h Olmetec 30 mg en q48h Mino 75 mg. Huidige 25D waarde 15 nmol/L en 1,25D is 62 pmol/L


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BeitragVerfasst: Mi Jan 09, 2013 8:17 am 
Hi Diesel

Verstehe ich das richtig erhöhte Homecystein Werte erhöhen Osteporose.

Mein Homecystein 16.6 ref <12

Danke Pit


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BeitragVerfasst: Do Jan 10, 2013 8:26 pm 
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Gast, Hausel, Pit :?

Ja, verhoogd Homocysteine is een risicofactor voor Osteoporose.

Osteoporose - Homocysteine – Osteoclasten

Zitat:
Homocysteine Levels and the Risk of Osteoporotic Fracture (77)

Citaat: An increased homocysteine level appears to be a strong and independent risk factor for osteoporotic fractures in older men and women.

Een verhoogd homocysteine gehalte blijkt een sterke en onafhankelijke risico factor voor fracturen, veroorzaakt door osteoporose, bij oudere mannen en vrouwen.

Increased Osteoclast Activity in the Presence of Increased Homocysteine Concentrations (78)

Citaat: Increased HCY concentrations specifically stimulate OC activity in vitro, suggesting a mechanistic role of HCY for bone resorption.

Verhoogde homocysteine concentraties stimuleren specifiek de activiteit van osteoclasten (OC) in vitro hetgeen een mechanische rol suggereert van homocysteine bij been resorptie.

Vitamin B12 Deficiency Stimulates Osteoclastogenesis via Increased Homocysteine and Methylmalonic Acid (79)

Citaat: On the basis of these results, we conclude that B12 deficiency may lead to decreased bone mass by increased osteoclast formation due to increased MMA and Hcy levels.

Op basis van deze resultaten concluderen wij dat een B12 deficiëntie kan leiden tot een afgenomen botdichtheid wegens verhoogde osteoclasten vorming als gevolg van de verhoogde MMA (Methylmalonzuur) en Hcy (homocysteine) waardes.

Homocysteine and Vitamin B12 Status Relate to Bone Turnover Markers, Broadband Ultrasound Attenuation, and Fractures in Healthy Elderly People (80)

Longitudinal Aging Study Amsterdam -- Hyperhomocysteine kan bijdragen in de ontwikkeling van Osteoporose.

Homocysteine as a Predictive Factor for Hip Fracture in Older Persons (81)

Verhoogd Homocysteine in Reuma artritis

Zitat:
Verhoogde homocysteine waardes komen regelmatig voor bij patiënten met Reuma artritis en dit zou in enkele gevallen de verklaring kunnen zijn van het verhoogde cardiovasculaire sterftecijfer in dergelijke patiënten.

Data suggereert dat, in patiënten aangedaan met Reuma artritis, homocysteine mogelijk niet alleen een belangrijke risico factor is voor de ontwikkeling van cardiovasculaire aandoeningen, maar tevens betrokken is bij de voortschrijding van gewrichtsschade.

Homocysteine enhences cytokine production in cultered synoviocytes from rheumatoid arthritis patients (68)

Diverse studies met betrekking hyperhomocysteine in Reuma arthritis (69,70,71,72)

Wat is overigens de meet eenheid van je homocysteine waarde? Bij een meet eenheid uitgedrukt in µmol/l is de vuistregel regel van een homcysteine streefwaarde als volgt:

Zitat:
Vuistregel homocysteine normaal waarde die je kunt hanteren is je leeftijd delen door 10 en de uitkomst vermenigvuldigen met 2. De gemeten Hct waarde mag niet hoger zijn dan de uitkomst van deze vuistregel.

Voor de volledigheid verwijs ik je naar de volgende info. met voetnoot verwijzing naar diverse literatuur studies.

Zijn Homocysteine en Calcitriol waarden functionele inflammatie markers in chronische aandoeningen?

http://b12vitaminetekortpodium.blogspot ... den_2.html

Diesel

_________________
B12 hydroxo- injecties ’95. Sublingaal methyl- en adenosyl-cobalamine tabl. ’08. Osteoporose '07. Koper en ceruloplasmine deficiëntie ’08. Sinds 2010 MP. med. q6h Olmetec 30 mg en q48h Mino 75 mg. Huidige 25D waarde 15 nmol/L en 1,25D is 62 pmol/L


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BeitragVerfasst: Fr Jan 11, 2013 3:49 am 
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Danke Diesel bist spitze :mrgreen:

Nun wird vieles klar.

Chlamydia pneumoniae und Helicobacter pylori kann persistierende Infektionen der Atemwege und des Verdauungstraktes. Es wurde postuliert, dass persistierende Infektionen mit diesen Bakterien aus den Blutgefäßen kann zu Arteriosklerose beitragen.
Vermutete Mechanismen, wie Helicobacter pylori das Risiko von Herz-und Gefäßerkrankungen erhöhen könnte enthalten ua eine erhöhte Plasma-Fibrinogen, CRP, Leukozyten Ebenen und Homocystein-Wert im Seropositivbefunde.

Zusammenfassung Liste Infektion Zusammenhang mit Mikroorganismen, einschließlich Chlamydia pneumoniae, Helicobacter pylori, Coxiella, Mycoplasma, etc. beteiligt Atheroskleros

Dr S sagt die neuersten Studien von 2011 haben 60.8% Chlamy P. die einen Schlaganfall haben.

Diesel deine Seite ist Super hast dir viel Arbeit gemacht Danke.

Gibt es eine andere Möglkeit den Homocysten zu senken .

Durch Mp bin ich nun postiv auf Mykroplasmen so ein s.........

Alex kann man die Seite auf Deutsch machen ?

Lg Pit


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BeitragVerfasst: So Jan 13, 2013 11:35 am 
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Hallo,

Hausel hat geschrieben:

Nun wird vieles klar.

Durch Mp bin ich nun postiv auf Mykroplasmen so ein s.........

Meer info over samenhang Homocysteine, Chlamydia pneumonia, Helicobacter pylori, Mycobacterie etc. in tal van degeneratieve aandoeningen.

Hyperhomocysteinemia associated with Chlamydia pneumonia infection in ischemic stroke: A hospital based study from South India

http://www.neurology-asia.org/articles/20091_001.pdf

Background and objective:
Zitat:
While Chlamydia pneumonia infection and hyperhomocysteinemia have been shown to contribute independently to the atherosclerotic risk, recent evidence has linked the association of C. pneumonia positivity and hyperhomocysteinemia in patients with established atherosclerosis.

Conclusion:
Zitat:
This study has shown that C. pneumonia seropositivity is linked with hyperhomocysteinemia in patients with ischemic stroke in a sample of South Indian population.

INTRODUCTION
Zitat:
Hypertension, diabetes and hyperlipidemia are the conventional risk factors for the development of atherosclerosis, but there is a growing interest in the newly described risk factors.1 Many studies have shown that C. pneumonia infection 2,3 and hyperhomocysteinemia 4 contribute independently to the atherosclerotic diseases in coronary and cerebral vessels. Recent evidence has linked C. pneumonia positivity and hyperhomocysteinemia in patients with established atherosclerosis.5-8

It is not clear if the positivity for C. pneumonia is the cause or the effect of hyperhomocysteinemia although the latter seems plausible.20 The theoretical basis of this association rests on the fact that, in vitro, the growth of C. pneumonia is enhanced in serum-free media and particularly by depletion of lysine or methionine.21 In human metabolism, homocysteine is produced by demethylation of methionine and defects in the recycling pathway (in which homocysteine is remethylated to methionine) can cause hyperhomocysteinemia.22

There are several limitations in our study. First, the sample size was small. Second, the secondary causes of hyperhomocysteinemia like vitamin B6, B12, and folic acid deficiency, and genetic factors for hyperhomocysteinemia were not evaluated.

Hyperhomocyst(e)inemia and Chlamydia pneumonia IgG seropositivity in patients with coronary artery disease

http://www.dach-liga-homocystein.org/Fa ... amydia.pdf

Discussion
Zitat:
The major finding of our study was a significant association between elevated plasma homocyst(e)ine concentrations and C. pneumoniae IgG seropositivity in patients with CAD. Furthermore, homocyst(e)ine concentrations corresponded significantly with chlamydial IgG antibody titers.

Zitat:
In conclusion, this study provides first evidence for an association between elevated plasma homocyst(e)ine concentrationes and IgG antibody titers against C. pneumonia in patients with CAD. At present, accurate determination of causality requires large numbers of observations, and our findings should be regarded as preliminary. However, if confirmed they have important implications for future investigations and a better understanding in the etiology of atherosclerosis.

Association of hyperhomocysteinemia and Chlamydia pneumonia infection with carotid atherosclerosis and coronary artery disease in Japanese patients

http://link.springer.com/article/10.100 ... 08-0607-2#

Correlation of hyperhomocysteinaemia and Chlamydia pneumoniae IgG seropositivity with coronary artery disease in a general population.

http://www.ncbi.nlm.nih.gov/pubmed/17974477

CONCLUSION:
Zitat:
Concurrent hyperhomocysteinaemia and chronic C. pneumoniae infection, as a single entity, was independently associated with coronary artery disease in the general population. This synergism may have important implications for risk-stratification and intervention trials.

B12 Mangel bei Chlamydia Pneumonie Infektionen: Dr. Stratton´s Empfehlungen 2005

http://www.chlamydiapneumoniae.de/%5Bme ... nfektionen

(B-12 Deficiency in CPN Infektion: Dr. Stratton´s 2005 recommendations)

Zitat:
II. Therapeutisches Regiment zur Behandlung eines Vitamin B12 Mangels
Viele Patienten mit systematischen/chronischen Chlamydien Infektion haben einen schleichenden und unerkannten zellulären Vitamin B12 Mangel. Der Mangel kann durch B12 Level (normalerweise normal oder erniedrigt) , Serum Homocysteine und Methylmalonate Level (eines oder beide erhöht) ermittelt werden.

Mycobacterium tuberculosis Complex in Arthersclerosis

http://www.lib.okayama-u.ac.jp/www/acta ... _6_247.pdf

Zitat:
Some of the traditional risk factors for artherosclerosis are diabetes, hypertension, gender, age, smoking, obesity, hypercholesterolemia, hyperhomocysteinemia and heridety. What ever the triggering factor for the development of artherosclerosis, the underlying process is inflammation, wich occurs as a response to injury.

Zitat:
The most frequently accused infectious agents are cytomegalovirus (CMV), Herpes simplex virus (HSV), Chlamydia pneumoniae (C. pneumonia), and Helicobacter pylori (H. pylori)

Chlamydia pneumoniae infection, inflammation and heat shock protein 60 immunity in asthma and coronary heart disease

http://herkules.oulu.fi/isbn9514269853/html/x1017.html

Atherosclerosis as an infectious disease
Zitat:
Infections may contribute to the development of atherosclerosis by inducing both inflammation and autoimmunity. A large number of studies have demonstrated a role of infectious agents, both viruses (cytomegalovirus, herpes simplex viruses, enteroviruses, hepatitis A) and bacteria (C. pneumoniae, H. pylori, periodontal pathogens) in atherosclerosis (reviewed in Danesh et al. 1997, Libby et al. 1997, Mattila et al. 1998, Epstein et al. 1999, Leinonen & Saikku 2002).

Zitat:
Recently, a new “pathogen burden” hypothesis has been proposed, suggesting that multiple infectious agents contribute to atherosclerosis, and that the risk of cardiovascular disease posed by infection is related to the number of pathogens to which an individual has been exposed (Zhu et al. 2000, Zhu et al. 2001a)

“number of pathogens to which an individual has been exposed” :idea: :arrow: MP :D

Diesel

_________________
B12 hydroxo- injecties ’95. Sublingaal methyl- en adenosyl-cobalamine tabl. ’08. Osteoporose '07. Koper en ceruloplasmine deficiëntie ’08. Sinds 2010 MP. med. q6h Olmetec 30 mg en q48h Mino 75 mg. Huidige 25D waarde 15 nmol/L en 1,25D is 62 pmol/L


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BeitragVerfasst: Mo Jan 14, 2013 3:01 am 
Hi Diesel

Das heist wenn IGG von Chlam. erhöht ist zeigt eine aktive Chlam. Infektion an.
Und dadurch kann Homecysten erhöht sein.

Danke Pit


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BeitragVerfasst: Do Jun 27, 2013 6:46 pm 
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Beiträge: 47
Wohnort: Nederland
Vitamin D: More May Not Be Better

http://www.newswise.com/articles/vitami ... -be-better

Zitat:
Muhammad Amer, M.D., M.H.S., an assistant professor in the Division of General Internal Medicine at the Johns Hopkins University School of Medicine. “At a certain point, more vitamin D no longer confers any survival benefit, so taking these expensive supplements is at best a waste of money.”

Zitat:
When they looked at deaths from all causes and cardiovascular disease specifically, those with blood levels of 21 nanograms per milliliter of 25-Hydroxyvitamin D — at the top of the range that the IOM considers “adequate” and at the low end of “normal” — cut their risk of death in half. Above 21 nanograms per milliliters, the data suggest that the protective effect appears to wear off.

Patiënten met Vit.D (25-OH) waarden onder de bovenwaarde van 21 ng/ml (rapport IOM) reduceren het risico op sterfte met de helft. (21 ng/ml = 52 nmol/l)

Zitat:
Beyond blood levels of 21 nanograms per milliliter, any additional increase in vitamin D was associated with an increase in CRP, a factor linked to stiffening of the blood vessels and an increased risk of cardiovascular problems. The team’s unpublished research also suggests a link between excess vitamin D and elevated homocysteine levels, another danger sign for cardiovascular disease.

Overvloed Vit.D + verhoogd homocysteine (1+1 = 2)

Do we have a bingo?

Zitat:
Still, he says, “most healthy people are unlikely to find that supplementation prevents cardiovascular diseases or extends their lives,” and there is no consensus among doctors on what is the right level of vitamin D in the blood for healthy people.

“There are a lot of myths out there and not enough data,” he concludes.

Diesel

_________________
B12 hydroxo- injecties ’95. Sublingaal methyl- en adenosyl-cobalamine tabl. ’08. Osteoporose '07. Koper en ceruloplasmine deficiëntie ’08. Sinds 2010 MP. med. q6h Olmetec 30 mg en q48h Mino 75 mg. Huidige 25D waarde 15 nmol/L en 1,25D is 62 pmol/L


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